Cloprostenol is a synthetic analog of prostaglandin F2α(PGF2α), and shows selective agonistic activity at the prostaglandin receptor.

Name: Cloprostenol Sodium (Synonyms: DL-Cloprostenol)

Chemical Name: (±)-9α,11α,15R-trihydroxy-16-(3-chlorophenoxy)-17,18,19,20-tetranor-prosta- 5Z,13E-dien-1-oic acid, monosodium salt.

Cas Number: 55028-72-3

Molecular Formula: C22H28O6ClNa

Molecular Weight: 446.9

Molecular Structure

Synonyms ·      (±)-16-m-chlorophenoxy tetranor PGF2α ·      DL-Cloprostenol

Biological Activity Cloprostenol sodium is a more water solute, crystalline form of cloprostenol than the free acid. Cloprostenol also known as ICI 80996, is a synthetic analog of prostaglandin F2α(PGF2α). It is 200 times and 100 times more potent than PGF2α in terminating pregnancy in hamsters and rats, respectively, without the side effects associated with PGF2α.1 The subcutaneous dose required for interrupting early pregnancy is species dependent, requiring approximately 1.25 µg/kg and 270 µg/kg in hamsters and rats, respectively. Cloprostenol is also a potent inhibitor of rat adipose precursor differentiation in primary cultures.

Applications: A potent FGP agonist.

Physical Appearance: White crystalline powder.

Solubility: Soluble in ethanol (10 mg/ml), DMSO (50 mg/ml), DMF (50 mg/ml), water (50 mg/ml), and PBS (pH 7.2) (1 mg/ml).

Storage Conditions: Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).

Additional information

SIZE (mg)	100 MG, 50 MG

Protocol

Cloprostenol Sodium

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